Amyloidosis and Renal Lesion Induced in Mice by Injection with Freund-Type of Adjuvant.

Abstract

A method has been described for the induction of amyloidosis in mice by injection of the Freund-type adjuvant. The M. butyricum, or oil and emulsifying agent alone were not effective. M. butyricum with either the oil or emulsifying agent was capable of inducing amyloid. N. asteroides or Group A streptococci could be substituted for M. butyricum but the incidence of amyloidosis was less. The present method, as compared with previous ones, requires fewer injections, and it produces a higher incidence of amyloidosis in a shorter time.