Ocular responses evoked by capsaicin and prostaglandin E2 are inhibited by a substance P antagonist
- 1 September 1983
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 39 (9), 996-998
- https://doi.org/10.1007/bf01989769
Abstract
Injection of capsaicin or prostaglandin E2 into the vitreous chamber of the rabbit eye resulted in miosis and breakdown of the blood-aqueous barrier, manifested in aqueous flare. Pretreatment with the neuronal blocker tetrodotoxin or the substance P antagonist (D-Pro2, D-Trp7,9)-SP1–11 greatly reduced the ocular responses to capsaicin and prostaglandin E2. The results suggest a role for neuronal substance P in the ocular response to injury.This publication has 26 references indexed in Scilit:
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