Reproductive endocrinology of female chimpanzees: A suitable model of humans
- 1 March 1976
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 1 (4), 657-668
- https://doi.org/10.1080/15287397609529364
Abstract
Similarities between reproductive processes in humans and chimpanzees have led to speculation that the chimpanzee might be an excellent reproductive‐endocrine model of humans. Data comparing patterns and concentrations of serum gonadotropins, prolactin, and sex steroids in female humans, chimpanzees, and rhesus monkeys sustain this concept. The striking evidence that levels of estrone, estradiol, estriol, progesterone, and chorionic gonadotropin are similar during human and chimpanzee pregnancy support the contention that chimpanzees, like humans but unlike rhesus monkeys, have a definitive fetoplacental unit. Likewise, during normal menstrual cycles serum patterns of LH, FSH, progesterone, and estradiol are similar in women and chimpanzees, but differ in rhesus monkeys. Thus by using the chimpanzee it may be possible to accurately assess the safety for human use of compounds that might affect reproductive‐endocrine processes without direct exposure to humans.Keywords
This publication has 35 references indexed in Scilit:
- Radioimmunoassay for Rhesus Monkey GonadotropinsExperimental Biology and Medicine, 1975
- Estrogens, Progesterone and Chorionic Gonadotropin in Pregnant Rhesus MonkeysEndocrinology, 1972
- Urinary Levels of Estrogens and Pregnanediol and Plasma Levels of Progesterone during the Menstrual Cycle of the Chimpanzee: Relationship to the Sexual SwellingEndocrinology, 1972
- Simultaneous Radioimmunoassay of Plasma FSH, LH, Progesterone, 17-Hydroxyprogesterone, and Estradiol-17β During the Menstrual CycleJournal of Clinical Endocrinology & Metabolism, 1972
- A Modification of the Rapid Method for the Assay of Plasma Estriol in Pregnancy: Use of Unconjugated3H-estriol To Correct for LossesJournal of Clinical Endocrinology & Metabolism, 1969
- THE BREEDING OF APES: EXPERIENCE AT THE YERKES REGIONAL PRIMATE RESEARCH CENTER AND A BRIEF REVIEW OF THE LITERATUREAnnals of the New York Academy of Sciences, 1969
- Concentration of Unconjugated Estrone and Estradiol in Peripheral Plasma in Nonpregnant Women Throughout the Menstrual Cycle, Castrate and Postmenopausal Women and in Men1Journal of Clinical Endocrinology & Metabolism, 1969
- Serum FSH and HCG During Human Pregnancy and Puerperium1Journal of Clinical Endocrinology & Metabolism, 1968
- Serum Follicle-Stimulating Hormone and Luteinizing Hormone Concentrations During the Menstrual Cycle as Determined by RadioimmunoassaysJournal of Clinical Endocrinology & Metabolism, 1967
- Species Specificity of FSH and LH as Determined by Radioimmunoassay.Experimental Biology and Medicine, 1967