THE IN VITRO PRODUCTION OF ANDROGENS BY FOLLICULAR TISSUE OF RABBITS
- 1 October 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 47 (2), 306-313
- https://doi.org/10.1530/acta.0.0470306
Abstract
Incubation in vitro of rabbit follicles in separate experiments with dehydro-epiandrosterone-C14 (DHEA-C14), progesterone-C14 and pregnenolone-H3 in the presence of FSH gave the following results 39% of the radioactivity of DHEA-C14 is converted to androstenedione and testosterone, while only 3% of the radioactivity of either progesterone-C14 or pregnenolone-H3 is found in the androgen fraction. From the ratio of testosterone to androstenedione formed from the 3 precursors, the results are interpreted to mean that DHEA and pregnenolone, and not progesterone, are precursors of androgens in the follicle.Keywords
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