Short term routine antibiotic prophylaxis in surgery

Abstract

The effect of two doses only of tobramycin (or gentamicin) plus lincomycin timed to cover the operative and immediate postoperative period was tested in a double blind trial. Evidence is presented that wound infection was reduced. No acquired bacterial resistance was encountered nor is this likely after such short term therapy. Routine use of this régime is recommended for all operations in which colonized viscera or infected body cavities have to be handled or opened.