Chlorpromazine: Direct Measurement of Differential Behavioral Effect
- 29 March 1968
- journal article
- clinical trial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3822), 1487-1489
- https://doi.org/10.1126/science.159.3822.1487
Abstract
A retarded child with a high stereotyped rocking rate was conditioned to pull a ball on a reinforcement schedule in which the fixed ratio aof rewarded to nonrewarded responses was 100. Results show no rocking movements during ball-pulling; but when ball-pulling was on extinction, rocking returned to its original rate. Chlorpromazine blocked rocking movements during extinction, but had no effect on ball-pulling. Delivery of one free reinforcer was sufficient to reinstate ball-pulling after extinction, but the stimulus properties of the free reinforcer were not affected by the drug.Keywords
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