Mechanism of Recovery from Systemic Herpes Simplex Virus Infection. I. Comparative Effectiveness of Antibody and Reconstitution of Immune Spleen Cells on Immunosuppressed Mice
- 31 July 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 142 (2), 163-174
- https://doi.org/10.1093/infdis/142.2.163
Abstract
The role of cellular immunity, humoral antibody, and interferon in recovery from primary systemic infection in mice due to herpes simplex virus type 1 (HSV-l) was studied. Immunosuppression by three methods—each of which was sufficient to suppress humoral and cellular immunity—markedly potentiated primary systemic HSV-1 infection. Immunosuppressed mice did not form neutralizing antibody to HSV-1, but passive transfer of physiologic amounts of neutralizing antibody as late as day 6 after infection exerted a protective effect. Passive transfer of 108 immune spleen cells on day 3 after infection was only partially protective and did not thereafter reverse the effect of X-irradiation on HSV-l infection. Furthermore, mice that received immune cells appeared to make sufficient antibody to explain the protective effect of the transferred cells. These results suggest that antibody to HSV-1 has a critical role in promoting recovery from primary infection in this model. The findings neither favor nor exclude a defensive role for immune cells in this experimental primary HSV-l infection.Keywords
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