Early Warning of Rejection?
- 5 May 1973
- Vol. 2 (5861), 261-265
- https://doi.org/10.1136/bmj.2.5861.261
Abstract
The urinary excretion of N-acetyl-β-D-glucosaminidase (NAG), β-galactosidase (GAL), β-glucosidase (GLU), and alkaline phosphatase (AP) was studied in 83 patients with renal allografts. Thirty of these patients had stable graft function and their urinary enzyme levels provided a range of normal values. Urinary lactic dehydrogenase (LDH) was estimated in 29 normal subjects and in 11 patients with renal allografts. Serum values for the five enzymes were also obtained. Urinary NAG excretion was abnormally high in 16 out of 17 (94%) episodes of acute rejection. The other urinary enzymes were raised less frequently. In nine patients studied before the onset of rejection urinary NAG activity rose up to three weeks before changes in other tests of renal function. Serum enzyme levels were not found to be of value in the diagnosis of rejection.Keywords
This publication has 10 references indexed in Scilit:
- The Immunological Follow up of Renal Allograft RecipientsProceedings of the Royal Society of Medicine, 1972
- FIBRIN DEGRADATION PRODUCTS IN RENAL PARENCHYMAL DISEASE STATES AND RENAL TRANSPLANT PATIENTSTransplantation, 1972
- The excretion of
acetyl -β-glucosaminidase and β-galactosidase by patients with renal diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1970 - The excretion of
acetyl -β-glucosaminidase and β-galactosidase following surgery to the kidneyClinica Chimica Acta; International Journal of Clinical Chemistry, 1970 - Urine Fibrinogen Fragments in Human Renal AllograftsNew England Journal of Medicine, 1968
- Sequential analysis of urinary enzymes in early diagnosis of parenchymal damage after renal homotransplantation.BMJ, 1968
- Urine and Serum Lysozyme Measurement in Renal Homotransplantation.Experimental Biology and Medicine, 1965
- SERUM AND URINARY LACTIC DEHYDROGENASE IN PATIENTS WITH RENAL HOMOTRANSPLANTS.1964
- Serum Lactic Dehydrogenase Activity: An Analytical Assessment of Current AssaysClinical Chemistry, 1963
- Studies on glucosaminidase. 4. The fluorimetric assay of N-acetyl-β-glucosaminidaseBiochemical Journal, 1961