The IFI‐56K and IFI‐54K interferon‐inducible human genes belong to the same gene family
- 11 April 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 231 (1), 164-171
- https://doi.org/10.1016/0014-5793(88)80724-5
Abstract
The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene.Keywords
This publication has 25 references indexed in Scilit:
- New inducers revealed by the promoter sequence analysis of two interferon-activated human genesEuropean Journal of Biochemistry, 1987
- Tumour necrosis factors α and β inhibit virus replication and synergize with interferonsNature, 1986
- Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblastsEuropean Journal of Biochemistry, 1986
- Full‐length sequence and expression of the 42 kDa 2–5A synthetase induced by human interferonFEBS Letters, 1986
- Molecular cloning, full‐length sequence and preliminary characterization of a 56‐kDa protein induced by human interferonsEuropean Journal of Biochemistry, 1986
- Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cellsCell, 1985
- A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferonsNature, 1983
- Hydrophobic moments and protein structureFaraday Symposia of the Chemical Society, 1982
- Human leukocyte and fibroblast interferons are structurally relatedNature, 1980
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970