The fate of certain organic acids and amides in the rabbit. 12. Aminohydroxybenzoic acids

Abstract

All of 7 aminohydroxybenzoic acids were excreted by the rabbit unconjugated to degrees varying from 10 to 71% of the dose, and all except 2-amino-3-hydroxy-benzoic acid as N-acetyl derivatives (14-62% of the dose). All the acids are excreted partly as O-conjugates either unacetylated or acetylated. All except 3-amino-2-hydroxy- and 4-amino-2-hydroxy-benzoic acids are excreted conjugated to a small extent with sulfuric acid (2-8% of the dose). No conjugation of the car-boxyl group was detected. A small amt. of decarboxylation of 4-amino-2-hydroxybenzoic acid was detected. Only 13% of a dose of 2-amino-3-hydroxybenzoic acid could be accounted for. 3-Amino-5-hydroxybenzoic acid was synthesized. Rp values for amino- and acetamido-hydroxybenzoic acids are recorded.