Inhibition of human gastric secretion by prostaglandin

Abstract

The synthetic analogue prostaglandin 15(R)15 methyl-E2 methyl ester is a potent inhibitor of basal and pentagastrin-induced acid secretion when given orally to male volunteers. Intravenous injection of the same dose of the analogue did not result in significant inhibition. The analogue is thought to reduce acid secretion by a direct effect on the parietal cell and differs from its parent prostaglandin E2 by its resistance to rapid enzymic degradation. The possible physiological significance of prostaglandin E2 in human gastric secretion is considered and the potential therapeutic role of its 15(R)15 methyl analogue is discussed.