SOME MECHANISMS INVOLVED IN THE REGULATION OF THE CIRCULATION

Abstract

An analysis is attempted, by means of the injection method, of the relations between cardiac output, circulation time and volume of actively circulating blood in the heart, lungs and great vessels in response to cardiovascular drugs and the arterio-venous fistula in dogs. Morphine decreases the velocity flow, increases the central congestion and leaves the volume flow unchanged. Atropine has probably the opposite effect. Adrenaline has the immediate effect of reducing both velocity and volume flow and increasing central congestion thus producing a situation analogous to cardiac decompensation. Amyl nitrite and the arterio-venous fistula increase the velocity and volume flow and decrease the degree of central congestion.