Chromosomal Abnormalities of Spleen Cells in Osteomyelosclerosis

Abstract

Cytogenetic investigations were carried out in a woman with osteomyelosclerosis by the method of karyotype analysis of the cells from cultured spleen aspirate and from the peripheral blood leukocytes. There was sharp preponderance of diploid metaphases in cultured blood contrary to the aneuploidy characterizing spleen aspirate culture. No Ph'' chromosomes were found. Myeloid metaplasia of the spleen in osteomyelosclerosis is more similar, with regard to chromosomal abnormalities, to neoplastic disease and acute leukemia, than to the chronic myeloid leukemia.