Genetic Alteration of Adenylic Pyrophosphorylase in Salmonella
- 8 November 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 142 (3593), 680-681
- https://doi.org/10.1126/science.142.3593.680
Abstract
A mutant of Salmonella typhimurium, resistant to inhibition by 2, 6-diaminopurine, differs from its sensitive wild-type parent by an altered adenylic acid pyrophosphorylase. The altered enzyme, though still active with adenine as substrate, is inactive in the conversion of diaminopurine to its nucleotide. It also differs from the wildtype enzyme in a number of physical and chemical properties.Keywords
This publication has 7 references indexed in Scilit:
- Metabolic Abnormalities of 2,6-Diaminopurine-Resistant Mutants of Salmonella typhimurium.Experimental Biology and Medicine, 1962
- Alterations in purine nucleotide pyrophosphorylases and resistance to purine analoguesBiochimica et Biophysica Acta, 1961
- Mechanism of resistance to 2,6-diaminopurine in Salmonella typhimuriumBiochimica et Biophysica Acta, 1961
- Purine Ribonucleotide Pyrophosphorylases and Resistance to Purine Analogues in Streptococcus faecalisPublished by Elsevier ,1961
- Reaction of 6-mercaptopurine with inosine- and guanosine- 5' -phosphate pyrophosphorylase purified from E. coliBiochemical Pharmacology, 1959
- Enzymic formation of 6-mercaptopurine ribotideBiochimica et Biophysica Acta, 1957