Human heterozygosity: a new estimate.
- 1 December 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (12), 6500-6504
- https://doi.org/10.1073/pnas.76.12.6500
Abstract
Several hundred polypeptides from 4 human diploid fibroblast cell lines were compared by high-resolution 2-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be < 1% for changes involving charged amino acids.This publication has 22 references indexed in Scilit:
- Genetic polymorphism in normal human fibroblasts as analyzed by two-dimensional polyacrylamide gel electrophoresis.Journal of Biological Chemistry, 1979
- Double-label autoradiography for comparison of complex protein mixtures after gel electrophoresisAnalytical Biochemistry, 1979
- Reevaluation of level of genic heterozygosity in natural population of Drosophila melanogaster by two-dimensional electrophoresis.Proceedings of the National Academy of Sciences, 1979
- Genetically Controlled Variation in the Shapes of EnzymesProgress in Nucleic Acid Research and Molecular Biology, 1979
- Stuttering: high-level mistranslation in animal and bacterial cells.Proceedings of the National Academy of Sciences, 1978
- High resolution two-dimensional electrophoresis of human plasma proteins.Proceedings of the National Academy of Sciences, 1977
- Tissue-specific differences in cultured human diploid fibroblastsExperimental Cell Research, 1977
- Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cellsCell, 1977
- Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.Proceedings of the National Academy of Sciences, 1977
- The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel ElectrophoresisJournal of Biological Chemistry, 1969