Comparison of endogenous and exogenous gastrin in stimulation of acid and pepsin secretion

Abstract

In dogs with a transplanted antral pouch, gastric fistula (GF), and Heidenhain pouch (HP), a graded increase in acid and pepsin response occurred from the GF and HP when acetylcholine chloride in concentrations ranging from 15 [mu]g/ml to 1,000 [mu]g/ml was perfused through the antral pouch. Maximal acid output occurred with concentrations of acetylcholine at or above 1,000 ng/ml. The maximal acid output from the GF was equal in response to endogenous gastrin and to exogenous hog gastrin; but the maximal acid output from the HP was smaller in response to endogenous gastrin than to exogenous hog gastrin. Maximal pepsin output with endogenous or exogenous gastrin stimulation was greater than with histamine. These studies show that dose-response relations for acid and pepsin secretion are similar with endogenous gastrin and exogenous hog gastrin in all major features.