35S 2-Hydroxyethanesulfonic Acid (Isethionic Acid) in Urine of Human Subjects Given 35S Taurine.

Abstract

The derivatives of orally administered 35g taurine have been studied in the urine of normal and mongoloid subjects. Using paper and ion exchange column chromato-graphy, 2-hydroxyethanesulfonic acid (isethionic acid) and sulfate were found to be the major derivatives. One major and 2 minor radioactive constituents remain unidentified. 14c taurine administration indicated that the isethionic acid is derived directly from taurine rather than from reincorporation of sulfate. The present study also demonstrates the usefulness of anion exchange column chromatography for the separation of 35S taurine derivatives.