Pathways and mechanisms of endocytic recycling

Abstract

Cargo that has been internalized by endocytosis is often recycled to the plasma membrane after being sorted in endosomes. Many proteins and lipids of the plasma membrane are internalized using clathrin-independent mechanisms. Studies of cargo that is internalized independently of clathrin have revealed new pathways and mechanisms of recycling. Precise temporal and spatial regulation of recycling pathways is crucial for diverse cellular processes, including cytokinesis, cell adhesion, morphogenesis, cell fusion, learning and memory.