Molecular studies of non-disjunction in trisomy 16.
- 1 March 1991
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 28 (3), 159-162
- https://doi.org/10.1136/jmg.28.3.159
Abstract
The origin of the additional chromosome in 26 trisomy 16 spontaneous abortions was studied using DNA probes for chromosome 16, including a probe for centromeric alpha sequences. We were able to determine the parent and meiotic stage of origin of trisomy in 22 cases, with all being attributable to maternal meiosis I non-disjunction. Furthermore, in each of the remaining four cases the results were compatible with this origin. Thus, it is likely that the high incidence of trisomy 16 results from an abnormal process acting at maternal meiosis I which more frequently involves chromosome 16 than other similar sized chromosomes. In studies of recombination, we found little evidence for an association between reduced or absent recombination and chromosome 16 non-disjunction; however, we were unable to rule out an effect of hyperrecombination.Keywords
This publication has 14 references indexed in Scilit:
- A centromere map of the X chromosome from trisomies of maternal originAnnals of Human Genetics, 1990
- CHROMOSOME-SPECIFIC ALPHA SATELLITE DNA FROM THE CENTROMERE OF HUMAN CHROMOSOME-161989
- Gene-centromere mapping and the study of non-disjunction in autosomal trisomies and ovarian teratomas.1989
- Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms pp. 622-643Cytogenetic and Genome Research, 1989
- Report of the committee on linkage and gene orderCytogenetic and Genome Research, 1989
- Maternal age in trisomyAnnals of Human Genetics, 1988
- Evidence for Reduced Recombination on the Nondisjoined Chromosomes 21 in Down SyndromeScience, 1987
- THE RELATIONSHIP BETWEEN MATERNAL AGE AND CHROMOSOME SIZE IN AUTOSOMAL TRISOMY1986
- TRISOMY IN MANAnnual Review of Genetics, 1984
- A cytogenetic study of 1000 spontaneous abortionsAnnals of Human Genetics, 1980