Phorbol ester induces c-sis gene transcription in stem cell line K-562.
Open Access
- 1 May 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (5), 1847-1850
- https://doi.org/10.1128/mcb.6.5.1847
Abstract
The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line K-562. This induction occurred at the transcriptional level, as determined by a nuclear runoff transcriptional assay, and was not a generalized effect of TPA, since the treatment of other hematopoietic cell lines and normal peripheral blood lymphocytes with TPA did not result in the appearance of c-sis mRNA.This publication has 31 references indexed in Scilit:
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