β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
- 1 April 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 344 (6268), 742-746
- https://doi.org/10.1038/344742a0
Abstract
Mice homozygous for a beta 2-microglobulin gene disruption do not express any detectable beta 2-m protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of gamma delta, CD4+8+ and CD4+8- T cells, but have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor alpha beta+ CD4-8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules.Keywords
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