Fetal Death from Nicotinamide-Deficient Diet and Its Prevention by Chlorpromazine and Imipramine
- 25 September 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3639), 1429-1430
- https://doi.org/10.1126/science.145.3639.1429
Abstract
Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.Keywords
This publication has 11 references indexed in Scilit:
- Pituitary Influence on Pyridine Nucleotide Metabolism of Rat LiverJournal of Biological Chemistry, 1964
- Prevention of Salicylate Teratogenicity in Immobilized Rats by Certain Central Nervous System Depressants.Experimental Biology and Medicine, 1964
- Multiple Congenital Abnormalities in the Rat Resulting from Acute Maternal Niacin Deficiency During Pregnancy.Experimental Biology and Medicine, 1963
- METABOLIC EFFECTS OF TRANQUILIZERS AND HYPOPHYSECTOMYAnnals of the New York Academy of Sciences, 1962
- Hormonal effects on DPN concentration in rat liverBiochimica et Biophysica Acta, 1961
- Production of Skeletal Malformations in the Offspring of Pregnant Mice Treated with 6-aminonicotinamideNeonatology, 1959
- Experimental Production of Congenital Malformations in Mammals by Metabolic ProcedurePhysiological Reviews, 1959
- Effect of Reserpine and Promazine on Diphosphopyridine Nucleotide Synthesis in LiverScience, 1958
- Niacin antagonists and chick developmentJournal of Experimental Zoology, 1957
- PRODUCTION OF CONGENITAL ANOMALIES IN MAMMALS BY MATERNAL DIETARY DEFICIENCIESPediatrics, 1957