Generation of free radicals from phenazine methosulfate, streptonigrin, and riboflavin in bacterial suspensions.
- 1 September 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (3), 887-891
- https://doi.org/10.1073/pnas.54.3.887
Abstract
Rubiflavin is a recently discovered antibiotic of unknown structure. Preliminary studies have indicated that it inhibits deoxyribonucleic acid (DNA) metabolism preferentially and that it interacts strongly with DNA in vitro. The finding that it forms free radicals intracellularly and that these may be bound to large molecules points to the possibility that this antibiotic may bring about its lethal action after binding to DNA as a free radical.This publication has 10 references indexed in Scilit:
- Interaction of the Radical Ion of Chlorpromazine with Deoxyribonucleic AcidJournal of the American Chemical Society, 1965
- The Site of Alkylation of Nucleic Acids by Mitomycin*Biochemistry, 1965
- Alkylation of Nucleic Acids by Mitomycin C and Porfiromycin*Biochemistry, 1965
- Spectroscopic Characteristics and Some Chemical Properties of N-Methylphenazinium Methyl Sulfate (Phenazine Methosulfate) and Pyocyanine at the Semiquinoid Oxidation LevelJournal of Biological Chemistry, 1964
- Phenethyl Alcohol Synergism with Mitomycin C, Porfiromycin, and StreptonigrinScience, 1964
- CROSSLINKING OF DNA BY ENZYMATICALLY OR CHEMICALLY ACTIVATED MITOMYCINS AND PORFIROMYCINS, BIFUNCTIONALLY "ALKYLATING" ANTIBIOTICS.1964
- The action of streptonigrin on bacterial DNA metabolism and on induction of phage production in lysogenic bacteriaVirology, 1963
- Mitomycin C: Chemical and Biological Studies on AlkylationScience, 1963
- Electron Paramagnetic Resonance in BiologyBiophysical Journal, 1962
- An upper limit to the protein content of the germinal substance of bacteriophage T2Virology, 1955