Immunologic Inhibition of Ultraviolet Radiation-Induced Tumor Suppressor Cell Activity
- 11 May 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 224 (4649), 615-617
- https://doi.org/10.1126/science.6231725
Abstract
Long-term exposure of C3H mice to ultraviolet radiation resulted in the formation of suppressor T cells that recognize ultraviolet radiation-induced regressor skin cancers as a class before the appearance of overt tumors. Administration of monoclonal antibodies to the product of the I-Jk subregion of the major histocompatibility complex or low doses of cyclophosphamide in vivo inhibited the development or activity of these cells. This activity of the monoclonal antibody was eliminated by adsorption on B10.BR (I-Jk) but not B10.D2 (I-Jd) splenocytes. These findings provide evidence that elements expressing the I-J determinant are important in regulating the host response prior to the overt development of ultraviolet radiation-induced skin cancers and suggest novel therapeutic approaches to malignancies or other diseases involving suppressor T cells in their pathogenesis.This publication has 17 references indexed in Scilit:
- Identification of an I-J+ antigen-presenting cell required for third order suppressor cell activation.The Journal of Experimental Medicine, 1983
- A molecular map of the immune response region from the major histocompatibility complex of the mouseNature, 1982
- Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated MiceScience, 1982
- Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.The Journal of Experimental Medicine, 1982
- Regulation of immune responses by I-J gene products. I. Production and characterization of anti-I-J monoclonal antibodies.The Journal of Experimental Medicine, 1981
- T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases.The Journal of Experimental Medicine, 1981
- MODIFICATION OF IMMUNOLOGICAL POTENTIAL BY ULTRAVIOLET RADIATIONTransplantation, 1977
- The I-J subregion codes for determinants on suppressor factor(s) which limit the contact sensitivity response to picryl chlorideThe Journal of Experimental Medicine, 1977
- Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.The Journal of Experimental Medicine, 1976
- A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.The Journal of Experimental Medicine, 1976