Evidence that Enzyme Polymorphisms Are Selectively Neutral, but Blood Group Polymorphisms Are Not
- 15 March 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4129), 1091-1092
- https://doi.org/10.1126/science.183.4129.1091
Abstract
Data on enzyme polymorphism and blood group polymorphism were examined with special reference to molecular evolution, by using a statistic that depends on neither population structure nor other ecological factors. The data of the former are consistent with the hypothesis of neutral mutant and random genetic drift, whereas the latter are in accord with the hypothesis of balanced selection.Keywords
This publication has 12 references indexed in Scilit:
- The Dilemma of Nearly Neutral Mutations: How Important Are They For Evolution and Human Welfare?Journal of Heredity, 1972
- Evidence for the Neutral Hypothesis of Protein PolymorphismScience, 1972
- Some invariant properties of a geographically structured finite population: distribution of heterozygotes under irreversible mutationGenetics Research, 1972
- Natural Selection and Genetic Drift in Protein PolymorphismNature, 1972
- Protein Variation and Systematics in Kangaroo Rats (Genus Dipodomys)Systematic Zoology, 1971
- The Genetics of Dacus oleae. V. Changes of Esterase Polymorphism in a Natural Population Following Insecticide Control-Selection or Drift?Evolution, 1971
- Protein Polymorphism as a Phase of Molecular EvolutionNature, 1971
- A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymesBiochemical Genetics, 1970
- Protein Polymorphism and Genic Heterozygosity in Two European Subspecies of the House MouseEvolution, 1969
- Polymorphic and monomorphic serum esterase heterogeneity in catostomid fish populationsBiochemical Genetics, 1967