The Chemical and Genetic Relationships Between Hemoglobins S and GSan Jose

Abstract

1. Comparison of the structures of the S-carboxymethylglobin derivatives of hemoglobins A, S and G shows that the only differences in the structure of these proteins resides in the βTpI peptides. 2. When structural methods are used to determine the types of hemoglobin in individuals from a family that possesses genes for hemoglobins A, S and G, it is possible to show that hemoglobins S and G are not inherited by nonallelic genes. 3. Previous difficulties in judging the hemoglobin types in this family by electrophoretic methods were caused by electrophoretically abnormal minor hemoglobin components. 4. The minor hemoglobin components which are observed in this family appear to arise by denaturation of the major hemoglobin component.