Plasmodium falciparum parasites induce interferon production in human peripheral blood ‘null’ cells in vitro
- 1 March 1983
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 5 (2), 165-172
- https://doi.org/10.1111/j.1365-3024.1983.tb00734.x
Abstract
Human peripheral blood mononuclear cells produced interferon (IFN) when stimulated by free P. falciparum parasites in vitro. Parasite-infected, intact erythrocytes were unable to induce IFN synthesis. When the IFN was characterized according to sensitivity to anti-IFN-.alpha. antibodies and pH 2 treatment it was found to consist of IFN-.alpha.. Cell fractionation procedures and analysis of each cell fraction with regard to natural killer (NK) cell activity and IFN-producing capacity revealed that both activities were confined to the same cell fraction. The possible relevance of the IFN-NK cell system in malaria is discussed.Keywords
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