Hyaluronidase Inhibitors in Body Fluids in Normal and Disease States

Abstract

Conclusions 1. A reliable biological method for the quantitative assay of small quantities of hyaluronidase or hyaluronidase inhibitor in the presence of body fluids is described. 2. Presumably, the conjugates of salicylates as well as salicylate itself in therapeutic concentrations have no inhibitory effect on testicular hyaluronidase in vitro. 3. Thermolabile hyaluronidase inhibitor has been found increased in a significant proportion of the sera of human malignancies in a small series studied. 4. Rheumatic states do not differ from the normal with respect to this inhibitor toward testicular hyaluronidase.