Immunoglobulin G subclass levels and antibody responses to the 2009 influenza A (H1N1) monovalent vaccine among human immunodeficiency virus (HIV)-infected and HIV-uninfected adults
Open Access
- 29 December 2011
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 168 (1), 135-141
- https://doi.org/10.1111/j.1365-2249.2011.04550.x
Abstract
Immunoglobulin (Ig)G levels are important for antibody vaccine responses and IgG subclass deficiencies have been associated with severe 2009 influenza A (H1N1) infections. Studies have demonstrated variations in immune responses to the H1N1 vaccine, but the aetiology of this is unknown. We determined the associations between pre-vaccination overall and influenza-specific IgG subclass levels and 2009 H1N1-specific antibody responses post-vaccination (robust versus poor at day 28) stratified by human immunodeficiency virus (HIV) status. Logistic regression models were utilized to evaluate whether pre-vaccination IgG subclass levels were associated with the antibody response generated post-vaccination. We evaluated 48 participants as part of a clinical study who were stratified by robust versus poor post-vaccination immune responses. Participants had a median age of 35 years; 92% were male and 44% were Caucasian. HIV-infected adults had a median CD4 count of 669 cells/mm3, and 79% were receiving highly active anti-retroviral therapy. HIV-infected participants were more likely to have IgG2 deficiency (versus 4%, P < 0·001). No association of pre-vaccination IgG subclass levels (total or influenza-specific) and the antibody response generated by HIN1 vaccination in either group was found. In summary, pre-vaccination IgG subclass levels did not correlate with the ability to develop robust antibody responses to the 2009 influenza A (H1N1) monovalent vaccine. IgG2 deficiencies were common among HIV-infected individuals but did not correlate with poor influenza vaccine responses. Further investigations into the aetiology of disparate vaccine responses are needed.Keywords
This publication has 15 references indexed in Scilit:
- Immunogenicity of a Monovalent 2009 Influenza A (H1N1) Vaccine in an Immunocompromised Population: A Prospective Study Comparing HIV-Infected Adults with HIV-Uninfected AdultsClinical Infectious Diseases, 2010
- Association between Severe Pandemic 2009 Influenza A (H1N1) Virus Infection and Immunoglobulin G2Subclass DeficiencyClinical Infectious Diseases, 2010
- Humoral and Cellular Response to Influenza Vaccine in HIV-Infected Children With Full Viroimmunologic Response to Antiretroviral TherapyJAIDS Journal of Acquired Immune Deficiency Syndromes, 2008
- Immunological Characterization of ConjugatedHaemophilus influenzaeType b Vaccine Failure in InfantsClinical Infectious Diseases, 2001
- Immunoglobulin Deficiencies and Impaired Immune Response to Polysaccharide Antigens in Adult Patients with Recurrent Community-acquired PneumoniaScandinavian Journal of Infectious Diseases, 1997
- Qualitative and quantitative analyses of the antibody response elicited by Haemophilus influenzae type b capsular polysaccharide–tetanus toxoid conjugates in adults with IgG subclass deficiencies and frequent infectionsClinical and Experimental Immunology, 1994
- Impaired Antibody Response toHaemophilus influenzaeType b Polysaccharide and Low IgG2 and IgG4 Concentrations in Apache ChildrenNew England Journal of Medicine, 1990
- Serum IgG subclass responses of humans to inactivated and live influenza A vaccines compared to natural infections with influenza AJournal of Medical Virology, 1990
- IgG SUBCLASS DEFICIENCIESAnnual Review of Medicine, 1987
- Antibody activity of IgG subclasses against pneumococcal polysaccharides after vaccinationAmerican Journal of Otolaryngology, 1985