SULFATHIAZOLE ERUPTIONS

Abstract

Local sulfathiazole therapy is now a well established procedure in the treatment of superficial pyogenic disorders of the skin.¹Most authors considered this to be a relatively innocuous type of treatment, but experience has indicated that unfavorable reactions, some of them quite severe, may occur.²This report details the types of reactions which have been described following local sulfathiazole therapy and also includes an account of 4 cases with allergic studies comprising our experiences with some of the more spectacular types of reactivity. Sams and Capland²reported an example of recurrent contact dermatitis following repeated applications of sulfathiazole powder to the ears for a recurrent chronic dermatitis. Subsequent oral administration of the drug precipitated a severe dermatitis of the ears, followed shortly by a widely disseminate eruption. A patch test with the sulfathiazole powder gave negative results. Miller²lists 5 cases of contact dermatitis due to