Projection structure of a gap junction membrane channel at 7 Å resolution
- 1 January 1997
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 4 (1), 39-43
- https://doi.org/10.1038/nsb0197-39
Abstract
Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant alpha 1 connexin (Cx43) reveal a ring of transmembrane alpha-helices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.Keywords
This publication has 38 references indexed in Scilit:
- The Gap Junction Communication ChannelCell, 1996
- Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of LateralityNew England Journal of Medicine, 1995
- Cardiac Malformation in Neonatal Mice Lacking Connexin43Science, 1995
- Glia-Neuron Intercellular Calcium SignalingDevelopmental Neuroscience, 1994
- Pathophysiology of Gap Junctions in Heart DiseaseJournal of Cardiovascular Electrophysiology, 1994
- Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle.Circulation Research, 1993
- Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growthThe Journal of Membrane Biology, 1991
- Connexin family of gap junction proteinsThe Journal of Membrane Biology, 1990
- Structure-activity relations of the cardiac gap junction channelAmerican Journal of Physiology-Cell Physiology, 1990
- Two configurations of a channel-forming membrane proteinNature, 1984