Synergistic Action of Cortisone and Total-Body Irradiation in Mice
- 1 October 1952
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 59 (4), 559-563
- https://doi.org/10.1148/59.4.559
Abstract
Inbred male white mice, 25 gm. body wt., received in 1 exposure either the approx. LD50/14 days or a sublethal X-ray dose (220 kV, 0.5 mm. Cu filter, HVL. 1.0 mm. Cu). Cortisone in doses of 1 mg. or 3 mg. was admd. subcut. once or twice prior to or after irradiation. Cortisone enhanced the lethal effect of total body irradiation irrespective ot the time of admn., (100% mortality of the animals exposed to the LD50). Mortality rate was also accelerated; this was more pronounced when cortisone was given after irradiation. Pretreatment with cortisone also caused a high mortality in mice exposed to the sublethal X-ray dose. Attempts to modify the cortisone-induced enhancement of total-body X-ray mortality by either glutathione or cysteine prior to irradiation failed completely.Keywords
This publication has 3 references indexed in Scilit:
- Sulfhydryl Inhibition as a Mechanism in the Effects of ACTH and Cortisone.Experimental Biology and Medicine, 1951
- Protective Action of Anoxic Anoxia Against Total Body Roentgen Irradiation of MammalsRadiology, 1950
- Further Studies on Modification of Sensitivity to X-rays by CysteineExperimental Biology and Medicine, 1950