Sulfhydryl Inhibition as a Mechanism in the Effects of ACTH and Cortisone.
- 1 April 1951
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 76 (4), 825-827
- https://doi.org/10.3181/00379727-76-18643
Abstract
Suppression or partial inhibition of cellular enzyme systems thru sulfhydryl deprivation as produced by ACTH and cortisone is considered. The influence of cortisone on the spread of India ink - hyaluronidase mixtures in the skin of white mice was tested. The skin spread was restricted by cortisone; this inhibition of skin spread was quickly and completely reversed by reduced glutathione admd. intraperitoneally. It is suggested that sulfhydryl deficiency may be one common denominator in the effect of the C11 oxygenated adrenal steroids on their wide-spread enzyme system inhibition.Keywords
This publication has 8 references indexed in Scilit:
- THE EFFECT OF ADRENOCORTICAL HORMONE ON THE DERMAL SPREADING OF INDIA INK IN NORMAL AND IN ADRENALECTOMIZED MICEAnnals of the New York Academy of Sciences, 1950
- ACTION OF SULPHUR COMPOUNDS ON CARBOHYDRATE METABOLISM AND ON DIABETESThe American Journal of the Medical Sciences, 1950
- Alteration in Permeability of Some Membranes by Hyaluronidase and Inhibition of this Effect by SteroidsExperimental Biology and Medicine, 1949
- THE ASSAY AND DISTRIBUTION OF COENZYME AJournal of Biological Chemistry, 1948
- PRODUCTION OF TEMPORARY DIABETES MELLITUS IN MAN WITH PITUITARY ADRENOCORTICOTROPIC HORMONE - RELATION TO URIC ACID METABOLISM1948
- Protective Effect of Glutathione and Cysteine Against Alloxan Diabetes in the Rat.Experimental Biology and Medicine, 1946
- ENZYME SYSTEMS CONTAINING ACTIVE SULFHYDRYL GROUPS. THE ROLE OF GLUTATHIONEScience, 1943
- The influence of thiol groups in the activity of dehydrogenases. IIBiochemical Journal, 1938