EFFECTS OF MITOMYCIN C ON HUMAN CHROMOSOMES
Open Access
- 1 November 1964
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 23 (2), 386-395
- https://doi.org/10.1083/jcb.23.2.386
Abstract
Mitomycin C inhibits mitosis and causes breaks and exchanges in the chromosomes of cultured human leukocytes. The distribution of breaks is nonrandom with a marked excess of breaks in the secondary constriction regions of chromosomes Nos. 1,9, and 16. When not broken, these regions frequently show extreme attenuation and negative heteropycnosis.Keywords
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