The Activity of Streptomycin in the Presence of Serum and Whole Blood.
- 30 November 1947
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 66 (3), 493-500
- https://doi.org/10.3181/00379727-66-16134
Abstract
The activity of streptomycin was not changed in the presence of fresh whole blood or serum when tested with a sensitive strain of Staphylococcus aureus. No enhancement of streptomycin activity was noted even when immune serum was added to the blood. Growth of a resistant strain of S. aureus was inhibited during the first 24 hrs. by streptomycin in concs. far < inhibitory cones., and this effect was augmented when serum or blood was present. Growth curves indicated that this inhibition was a direct interference with bacterial metabolism rather than combination with or inactivation of labile constituents in the medium. The bactericidal and bac-teriostatic activity of streptomycin are dissociated phenomena.Keywords
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