Inhibitory Effects of Chloramphenicol on the Histogenetic Aggregation of Dissociated Cells
- 1 January 1964
- journal article
- research article
- Published by Genetics Society of Japan in The Japanese Journal of Genetics
- Vol. 38 (4), 257-260
- https://doi.org/10.1266/jjg.38.257
Abstract
As test mate-rials 5 to 7 day chick embryos were used, in which the body was dissociated with trypsin to make a suspension of single cells after removal of the head region. The inhibitory effects of chloramphenicol dissolved in the nutrient fluid at various concentrations, as an inhibitor of protein synthesis, were observed on the histogenetic aggregation of dissociated embryonic chick cells. It was suggested that the chloramphenicol does not damage primarily the cells, but does inhibit cell-aggregation by blocking protein synthesis. It was also assumed that the dissociated cells may retain the genetic information necessary for the synthesis of a substance or substances which would promote the histogenetic aggregation.This publication has 6 references indexed in Scilit:
- Inhibition of Adhesiveness and Aggregation of Dissociated Cells by Inhibitors of Protein and RNA SynthesisScience, 1963
- Changes in aggregation and differentiation of cartilage cells grown in monolayer culturesExperimental Cell Research, 1963
- Inhibition by glucosamine of aggregation of dissociated embryonic cellsDevelopmental Biology, 1963
- The role of temperature in the control of aggregation of dissociated embryonic cellsExperimental Cell Research, 1962
- Analysis of cell recombinations in experimental synthesis of tissuesin vitroJournal of Cellular and Comparative Physiology, 1962
- Rotation-mediated histogenetic aggregation of dissociated cellsExperimental Cell Research, 1961