INABILITY OF THYMINE-DEPENDENT MUTANTS OF BACTERIOPHAGE T4 TO INDUCE THYMIDYLATE SYNTHETASE
- 1 April 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 53 (4), 874-881
- https://doi.org/10.1073/pnas.53.4.874
Abstract
Infection of Escherichia coli by three thymine-requiring mutants of T4 phage induced little or no dTMP synthetase compared to the wild-type controls. A fourth mutant, td15, was clearly "leaky." At the same time a number of other phage-induced enzymes reached normal levels. These findings suggest that the mutations are related to thymidylate synthetase but do not indicate the nature of the mutations.Keywords
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