Cholesterogenesis: Derepression in Extrahepatic Tissues with 4-Aminopyrazolo [3,4- d ]pyrimidine
- 3 September 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4256), 903-905
- https://doi.org/10.1126/science.948751
Abstract
Administration of 4-aminopyrazolo [3,4-d] pyrimidine decreased serum cholesterol levels in the rat to less than 5 milligrams per deciliter. Coincident with this change, there was a 2.1 - to 16.0-fold increase in the rate of sterol synthesis in seven extrahepatic tissues. This suggests that cholesterol carried in serum lipoproteins plays a major role in regulating sterol synthesis in many extrahepatic tissues.This publication has 23 references indexed in Scilit:
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