Regulation of Cholesterol Metabolism
- 14 May 1970
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 282 (20), 1128-1138
- https://doi.org/10.1056/nejm197005142822005
Abstract
THE central features of the mechanisms by which cholesterol metabolism is regulated in intact animals were clearly elucidated in 1933 by Schoenheimer and Breusch1 — namely, that the synthesis, absorption and destruction of cholesterol in the mammal is controlled by complex interlocking feedback mechanism (or mechanisms), of which bile acids and cholesterol themselves are the principal mediators. In view of the fact that this superstructure for cholesterol metabolism was developed before the introduction of isotopic technics into biologic research, it is surprising that the intimate details of the regulatory mechanisms themselves and the means by which the regulatory mechanisms interdigitate . . .Keywords
This publication has 47 references indexed in Scilit:
- Absorption of bile acids from the large bowel in manJCI Insight, 1968
- Biosynthetic origin of serum cholesterol in the squirrel monkey: evidence for a contribution by the intestinal wallJCI Insight, 1968
- Cholesterol biosynthesis in rabbit blood and bone marrow: Effect of hematopoietic stimulation and dietary cholesterolBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1966
- Idiopathic Hypercholesterolemia: Demonstration of an Impaired Feedback Control of Cholesterol Synthesis in vivoThe Tohoku Journal of Experimental Medicine, 1965
- BODY CHOLESTEROL METABOLISM IN MAN. I. THE EQUILIBRATION OF SERUM AND TISSUE CHOLESTEROL*†JCI Insight, 1962
- BODY CHOLESTEROL METABOLISM IN MAN. II. MEASUREMENT OF THE BODY CHOLESTEROL MISCIBLE POOL AND TURNOVER RATE*†JCI Insight, 1962
- Dynamic Aspects of Cholesterol Metabolism in Different Areas of the Aorta and Other Tissues in Man and Their Relationship to AtherosclerosisCell Metabolism, 1960
- FATTY ACID, CHOLESTEROL, AND ACETOACETATE BIOSYNTHESIS IN LIVER HOMOGENATES FROM NORMAL AND STARVED GUINEA PIGSCanadian Journal of Biochemistry and Physiology, 1960
- EFFECT OF STARVATION ON CHOLESTEROL BIOSYNTHESISIN VITROCanadian Journal of Biochemistry and Physiology, 1955