The developmental analysis of an embryonic lethal (c6H) in the mouse

Abstract

A development study of the effects of the c⁶¹¹ allele at the albino locus has identified the c^6H homozygote as an early postimplantation lethal. Homozygous c^6H embryos can first be recognized at days of gestation by abnormalities of the ectopiacental cone and parietal endoderm. At days, mutant embryos appear severely retarded with obvious abnormalities in all germ layers. All c^6H homozygotes are dead and resorbed by 8 days of development. It is proposed that the mutation interferes with the normal differentiation of the parietal endoderm, ectoplacental cone and extra-embryonic ectoderm of the egg cylinder.