Effect of High Levels of Dietary Vitamin E on Liver and Plasma Lipids and Fat Soluble Vitamins in Rats
- 1 August 1977
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 107 (8), 1418-1426
- https://doi.org/10.1093/jn/107.8.1418
Abstract
The effect of low, moderate and high dietary vitamin E (ranging from 0 to 25,000 IU/kg diet) on the levels of α-tocopherol, total lipids, cholesterol and vitamin A in liver and plasma of rats fed for 8 and 16 months was studied. A logarithmic relationship was observed between dietary levels of vitamin E and the concentrations of this vitamin in liver and plasma. The total α-tocopherol in whole liver of rats fed different levels of dietary vitamin E for 16 months was approximately double in comparison to rats fed for 8 months. Total lipids in liver were significantly increased by excess vitamin E supplementation in rats fed for 8 months, but not in rats fed for 16 months. There was no significant change observed in liver cholesterol level at 16 months. Plasma total lipids and cholesterol were lowered by vitamin E deficiency and also by dietary levels higher than 2,500 IU vitamin E/kg diet in rats fed for 16 months. Liver vitamin A storage was 4.5 times higher in rats supplemented with vitamin E than in rats without any supplement, but the effect of excess dietary vitamin E was no different from that of normal level (25 IU/kg diet). The findings of our long-term study are compared with the results of other short-term studies and the implications are discussed.Keywords
This publication has 25 references indexed in Scilit:
- Effect of High Levels of Dietary Vitamin E on Liver and Plasma Lipids and Fat Soluble Vitamins in RatsJournal of Nutrition, 1977
- KINETICS OF TISSUE α‐TOCOPHEROL DEPLETION AND REPLETIONAnnals of the New York Academy of Sciences, 1972
- INTAKE AND ABSORPTION OF TOCOPHEROL*Annals of the New York Academy of Sciences, 1972
- Excessive Dietary Vitamin E: Its Alleviation of Hypervitaminosis A and Lack of ToxicityPoultry Science, 1970
- On the relationship between vitamin A and vitamin E in the ratBritish Journal of Nutrition, 1968
- A new assay for cholesterol and cholesterol esters in serum which is not affected by bilirubinClinica Chimica Acta; International Journal of Clinical Chemistry, 1962
- Absorption and Distribution of Vitamin E in the TissuesPublished by Elsevier ,1962
- MATHEMATICAL RELATIONSHIP BETWEEN LOGDOSE α-TOCOPHERYL ACETATE AND PLASMA TOCOPHEROL IN THE RATTHE JOURNAL OF VITAMINOLOGY, 1960
- The Vitamin E Potency of Alfalfa as Measured by the Tocopherol Content of the Liver of the Chick ,Poultry Science, 1957
- The effect of vitamin E deficiency on the vitamin A reserves of the ratBiochemical Journal, 1940