Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4‐phosphate in intact human platelets
- 20 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 195 (1-2), 115-118
- https://doi.org/10.1016/0014-5793(86)80142-9
Abstract
The present study investigates the effect of compounds that are known to elevate cAMP on the phospholipid metabolism of platelets. Prostaglandin E1, forskolin and isobutylmethylxanthine induce an increase in [32P]-phosphatidylinositol 4-phosphate (PIP) in platelets prelabelled with [32P]orthophosphate. Possible roles of this phenomenon are discussed in view of the inhibitory effect of cAMP elevation on platelet activation.Keywords
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