Identification of HLA-DRw52 associated antigens using HLA class II allogenotyping
- 1 November 1988
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 32 (5), 278-285
- https://doi.org/10.1111/j.1399-0039.1988.tb01667.x
Abstract
The HLA-DR antigens DRw8, DRw11, DRw12, DRw13, DRw14 and DRw17 are strongly associated with the supertypic specificity DRw52. This association has been used to assist in assignment of serological specificity. However, difficulties in the identification of these antigens arise since they are serologically crossreactive. This report describes the application of restriction fragment length polymorphism (RFLP) allogenotyping to assist in the positive identification of DRw8, DRw11, DRw12 DRw13, DRw14, DRw17, DRw52a and DRw52b, and in addition describes further subypes defined by RFLP which correlate with DQ or Dw associations. We also describe a novel TaqI/DR.beta. RFLP in a Caucasian family which types serologically as DRw12.This publication has 10 references indexed in Scilit:
- A DNA-RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL-DEFINED AND ILL-DEFINED HLA-DR AND DQ ALLELES, INCLUDING DRw10Transplantation, 1988
- Association of HLA-DRBr with HLA-DQw3Tissue Antigens, 1988
- Oligonucleotide genotyping shows that alleles at the HLA-DR ? III locus of the DRw52 supertypic group segregate independently of known DR or Dw specificitiesImmunogenetics, 1987
- HLA-DR allogenotyping using exon-specific cDNA probes and application of rapid minigel methodsMolecular Immunology, 1986
- Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificityNature, 1986
- Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-DPublished by Springer Nature ,1986
- Alloantisera Against Human Class II Antigens: Definition and MethodologyPublished by Springer Nature ,1986
- Structure, Sequence and Polymorphism in the HLA‐D RegionImmunological Reviews, 1985
- Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genesNature, 1984
- Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.Proceedings of the National Academy of Sciences, 1982