The analgetic properties of piroxicam in animals and correlation with expreimentally determined plasma levels
- 1 April 1980
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 10 (1-2), 31-37
- https://doi.org/10.1007/bf02024176
Abstract
In animal antinociceptive tests responsive to nonsteroidal anti-inflammatory drugs (NSAID), piroxicam is an extremely potent and effective analgetic at doses of 1–2 mg/kg p.o. In mice the plasma half-life and duration of analgetic action is short (t1/2=1.7 h), unlike man, wherein piroxicam exhibits an exceptionally long duration of action (half-life 40–45 h). An excellent correlation is observed between plasma levels and analgetic activity in the writhing test in mice suggesting that piroxicam will exhibit potent and long-lasting analgetic activity in man.This publication has 9 references indexed in Scilit:
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