Calcium dependency of the inhibitory effect of antidiuretic hormone on in vitro renin secretion in rats.
- 1 June 1981
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 315 (1), 21-30
- https://doi.org/10.1113/jphysiol.1981.sp013729
Abstract
Synthetic arginine-vasopressin (ADH or antidiuretic hormone) inhibited renin secretory rate of rat renal cortical slices. The response was concentration-dependent and was maximal at 0.1 U ml-1. Ca depletion (incubation of slices in medium containing Na2EGTA [ethylene glycol bis (.beta.-aminoethyl ether) tetraacetate] and no added CaCl2) stimulated renin secretion and eventually abolished the inhibitory effect of ADH. Both effects were reversible. The Ca antagonist D-600 [methoxyverapamil] at 0.5 .mu.M, reversed the inhibitory effect of K depolarization on secretory rate but had no effect on secretory rate of non-depolarized slices. In the presence of 0.5 .mu.M-D-600, ADH inhibited the secretory rate of either depolarized or non-depolarized slices. These results confirm and extend previous observations suggesting that Ca plays an inhibitory coupling role in the control of renin secretion. They suggest that although Ca influx through voltage-sensitive Ca channels influences the secretory activity of juxtaglomerular cells, ADH activates an independent pathway for Ca mobilization.This publication has 27 references indexed in Scilit:
- Effect of D‐600 on inhibition of in vitro renin release in the rat by high extracellular potassium and angiotensin II.The Journal of Physiology, 1980
- Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices.The Journal of Physiology, 1979
- Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth MuscleAnnual Review of Pharmacology and Toxicology, 1977
- Cellular actions of vasopressin in the mammalian kidneyKidney International, 1976
- Antidiuretic hormone and renin in rats with diabetes insipidusEuropean Journal of Pharmacology, 1974
- CALCIUM DEPENDENCE OF THE INHIBITORY EFFECT OF ANGIOTENSIN ON RENIN SECRETION IN THE ISOLATED PERFUSED KIDNEY OF THE RATBritish Journal of Pharmacology, 1974
- Renin release in anesthetized ratsKidney International, 1973
- Effect of an increase and of lack of antidiuretic hormone on plasma renin activity in the ratLife Sciences, 1971
- Inhibition of Renin Release in the Dog by Vasopressin and VasotocinCirculation Research, 1968
- Inhibition of Renin Release by Vasopressin and AngiotensinCardiovascular Research, 1967