The secretion of prostaglandin F from the autotransplanted uterus of the ewe

Abstract
The effects of estradiol-17.beta. and progesterone on the ability of the autotransplanted sheep uterus to release PGF (prostaglandin F) into the uterine vein were studied. In the normal estrous cycle PGF is released into the uterine vein in increasing amounts after day 12. This initial release of PGF may be in response to secretion of progesterone by the corpus luteum for 7-10 days and further release is facilitated by the subsequent fall of progesterone levels and the rise in secretion of estradiol from the preovulatory follicle.