Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.
- 1 September 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (9), 5525-5526
- https://doi.org/10.1073/pnas.77.9.5525
Abstract
The synthetic .beta.-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment [.beta.-endorphin-(6-31) and .beta.-endorphin-(20-31)] inhibit morphine or .beta.-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide .beta.-endorphin-(1-15) has no inhibitory activity. Endogenous inhibiting peptides may exist in the brain which play a role in the regulation of endorphin actions.This publication has 9 references indexed in Scilit:
- A protein-lipid model of the opiate receptorLife Sciences, 1980
- α-endorphin, γ-endorphin and their des-tyrosine fragments in rat pituitary and brain tissueLife Sciences, 1980
- Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.Journal of Biological Chemistry, 1979
- Interaction of iodinated human [D-Ala2]beta-endorphin with opitate receptors.Journal of Biological Chemistry, 1979
- SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH VARIOUS CHAIN LENGTHSInternational Journal of Peptide and Protein Research, 1978
- The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptideEuropean Journal of Pharmacology, 1978
- LEU-5-ENKEPHALIN-H-3 SPECIFIC BINDING TO SYNAPTIC MEMBRANE - COMPARISON WITH DIHYDROMORPHINE-H-3 AND NALOXONE-H-31978
- Endogenous opioid peptides: multiple agonists and receptorsNature, 1977
- Synthesis and analgesic activity of human .beta.-endorphinJournal of Medicinal Chemistry, 1977