Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin‐releasing hormone in the perfused stomach of anaesthetized rats
Open Access
- 1 May 1983
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 79 (1), 297-303
- https://doi.org/10.1111/j.1476-5381.1983.tb10524.x
Abstract
1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocriptine or methamphetamine inhibited the TRH-stimulated gastric acid secretion; these drugs did not influence bethanechol-induced acid secretion. 4 Haloperidol and metoclopramide prevented the antisecretory effects of apomorphine, bromocriptine and methamphetamine. 5 The present study suggests that central dopamine receptor stimulation inhibits intraventricular TRH-induced gastric acid secretion in rats.This publication has 27 references indexed in Scilit:
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