The role of cerebral blood volume changes in brain specific-gravity measurements
- 1 May 1985
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 62 (5), 704-710
- https://doi.org/10.3171/jns.1985.62.5.0704
Abstract
Cerebral blood volume (CBV) was calculated in gerbils from specific-gravity (SG) changes between normal and saline-perfused brains. Furthermore, changes in CBV were investigated during ischemia using carbon-14-labeled dextran (MW 70,000) as an intravascular marker. Both data were used to evaluate the possible error due to a change in CBV on the measurement of ischemic brain edema by the SG method. The methodological error found was 0.0004 for a 100% CBV change. This error is insignificant, being less than the standard deviation in the SG measured for the gerbil cortex (SG 1.0494 +/- 0.0006). Thus, CBV changes are not responsible for the SG variations observed during the first phase of ischemia. These variations are better explained as an increase of brain water content during ischemia.Keywords
This publication has 15 references indexed in Scilit:
- Evolution and resolution of oedema following severe temporary cerebral ischaemia in the gerbil.Journal of Neurology, Neurosurgery & Psychiatry, 1984
- Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 2. Results in Normal Subjects and Brain Tumour and Stroke PatientsJournal of Cerebral Blood Flow & Metabolism, 1983
- Regional Brain Blood Flow, Blood Volume, and Haematocrit Values in the Adult RatJournal of Cerebral Blood Flow & Metabolism, 1983
- An improved gravimetric measure of cerebral edemaJournal of Neurosurgery, 1982
- Are prostaglandins involved in experimental ischemic edema in gerbils?Stroke, 1981
- Microcirculatory obstruction in focal cerebral ischemia: albumin and erythrocyte transit.Stroke, 1981
- Cerebral blood flow and edema following carotid occlusion in the gerbil.Stroke, 1980
- A simple gravimetric technique for measurement of cerebral edemaJournal of Neurosurgery, 1978
- Pathophysiologic Aspects of Ischemic EdemaPublished by Springer Nature ,1976
- In vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey.Circulation Research, 1975