Diabetes Due to Secretion of an Abnormal Insulin
- 17 January 1980
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 302 (3), 129-135
- https://doi.org/10.1056/nejm198001173020301
Abstract
A 51-year-old, nonobese man with diabetes mellitus had marked hyperinsulinemia (70 to 120 μU per milliliter; 502 to 860 pmol per liter) and fasting hyperglycemia (140 to 170 mg per 100 ml; 7.8 to 9.4 mmol per liter). Plasma proinsulin, glucagon, growth hormone, and cortisol levels were normal; insulin antibodies and insulin-receptor antibodies were not detected. The patient showed relatively normal insulin sensitivity, and insulin receptors on circulating monocytes were within the normal range.This publication has 39 references indexed in Scilit:
- A structurally abnormal insulin causing human diabetesNature, 1979
- Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.Journal of Clinical Investigation, 1975
- Cooperativity in ligand binding: A new graphic analysisBiochemical and Biophysical Research Communications, 1975
- Binding and degradation of 125I-labelled insulin by isolated rat fat cellsBiochimica et Biophysica Acta (BBA) - General Subjects, 1973
- Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranesBiochemical and Biophysical Research Communications, 1971
- Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetesJournal of Clinical Investigation, 1970
- Immunological reactivity of insulin to sepharose coupled with insulin-antibody—Its use for the extraction of insulin from serumBiochemical and Biophysical Research Communications, 1970
- Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide GelsNature, 1962
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962
- The prediabetic stateAmerican Journal Of Medicine, 1961